Safety of atorvastatin in the collaborative atorvastatin. The safety and tolerability of atorvastatin 10 mg in the. An analysis from the collaborative atorvastatin diabetes study cards previous article solutesolver. This question is for testing whether or not you are a human visitor and to prevent automated spam submissions. The collaborative atorvastatin diabetes study cards is the first large primary prevention study to focus specifically on the role of a statin in patients aged 4075 years with type 2 diabetes, but no signs or symptoms of preexisting vascular disease and who had only. Objective to assess the representativeness of the heart protection study hps and the collaborative atorvastatin diabetes study cards for incident statin users.
These guidelines are based on numerous trials showing a benefit for statin therapy both as primary and secondary prevention of cardiovascular disease and mortality 27. Renal effects of atorvastatin and rosuvastatin in patients. The aim of the collaborative atorvastatin diabetes study cards was to assess the effectiveness of 10 mg of atorvastatin daily versus placebo in the primary prevention of cardiovascular disease in patients with type 2 diabetes. The american diabetes association has recommended using statins a class of drug used to lower cholesterol levels for patients with type 2 diabetes. Atorvastatin reduced major cardiovascular disease events. The collaborative atorvastatin diabetes study cards randomized placebocontrolled trial.
Atorvastatin, sold under the brand name lipitor among others, is a statin medication used to prevent cardiovascular disease in those at high risk and treat abnormal lipid levels. Design of the collaborative atorvastatin diabetes study. Subjects and methods a total of 2,838 patients, who were aged 40 to 75 years and had type 2 diabetes without a documented history of cardiovascular disease and without elevated ldlcholesterol, were recruited from 32 centres in the uk and ireland and randomly allocated to atorvastatin. Main outcome measures we determined the proportions of realworld.
Safety of atorvastatin in the collaborative atorvastatin diabetes study cards the safety and efficacy of sta the safety and efficacy of statins for cvd prevention is well established, yet some physicians have concerns about the longterm safety of this class. The collaborative atorvastatin diabetes study cards is the first randomized controlled trial that assessed the effectiveness and safety of using atorvastatin in patients with type 2 diabetes. Primary prevention of cardiovascular disease with atorvastatin in. A post hoc analysis of data from the collaborative atorvastatin diabetes study cards, a randomised, placebocontrolled trial of 2,838.
Colhoun hm, betteridge dj, durrington pn, hitman ga, neil ha, livingstone sj, thomason mj, mackness mi, charltonmenys v, fuller jh. Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the collaborative atorvastatin diabetes study cards. The study received ethical approval both centrally and at each participating institution, and each patient gave written. Pdf design of the collaborative atorvastatin diabetes study. Kdigo clinical practice guideline for lipid management in. A landmark lipitor study of patients with type 2 diabetes. An overview of cards collaborative atorvastatin diabetes. Collaborative atorvastatin diabetes study cards and fol lowed for 3. Evidence for the use of statins in patients with diabetes primary prevention trials in diabetes current clinical practice is based on relatively few randomized, control tri als.
Pdf effects of atorvastatin on kidney outcomes and. The safety and tolerability of atorvastatin 10 mg in the collaborative. Lipid management in type 2 diabetes clinical diabetes. Costeffectiveness of atorvastatin in the prevention of. The trial was stopped 2 years earlier than planned because of significant benefit at the second interim analysis. The percentages of patients experiencing treatment associated adverse events. What is the abbreviation for collaborative atorvastatin diabetes study. We conducted a post hoc analysis to compare the efficacy and safety of atorvastatin among 1,129 patients aged 6575 years at randomization with 1,709 younger patients in the collaborative atorvastatin diabetes study cards. The collaborative atorvastatin diabetes study cards was a doubleblind, randomized, placebocontrolled, multicenter trial of atorvastatin 10 mgday for the primary prevention of cvd in type 2 diabetes. Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes cards overview 1 a multicenter randomized placebo controlled trial to determine hard outcomes of atorvastatin 10mg vs. Abstract background there are few data on the role of lipid lowering in the primary prevention of coronary heart disease chd in diabetic. Atorvastatin in patients with type 2 diabetes mellitus.
Patients with type 2 diabetes and no prior cvd n 2,838. Collaborative atorvastatin diabetes study cards 2838 primary prevention patients no ascvd with type 2 diabetes at least 1 other cv risk factor such as smoking, hypertension, retinopathy, or microalbuminuria ldlc levels. The primary objective is to investigate whether treatment with the hydroxymethylglutaryl coenzyme a reductase inhibitor. Trials like the collaborative atorvastatin diabetes study cards, proved beyond doubt that patients with type 2 diabetes and other risk factors for cvd should be treated with a statin, apparently disregarding their.
Common side effects include joint pain, diarrhea, heartburn, nausea, and muscle pains. Are statin trials in diabetes representative of realworld. The collaborative atorvastatin diabetes study cards is a prospective, randomized, placebocontrolled trial designed to compare the effects of atorvastatin with placebo in preventing primary coronary events in diabetic patients. Ironically, there is a very compelling clinical trial showing the value of one statin, lipitor atorvastatin, in type 2 diabetes the collaborative atorvastatin diabetes study known as cards. The collaborative atorvastatin diabetes study cards is a multicentre, randomized, placebocontrolled, doubleblind clinical trial of primary. Population 56 963 patients with diabetes initiating statin use from 2005 to 2008. A webbased tool for modeling urea kinetics for a broad range of hemodialysis schedules in multiple patients. Atorvastatin reduced major cardiovascular disease events in type 2 diabetes mellitus colhoun hm, betteridge dj, durrington pn, et al. In the collaborative atorvastatin diabetes study cards, the effect of lipitor on cardiovascular disease cvd endpoints was assessed in 2838 subjects 94% white, 68% male, ages 4075 with type 2 diabetes based on who criteria, without prior history of cardiovascular disease and with ldl. Collaborative atorvastatin diabetes study american.
Action to control cardiovascular risk in diabetes eye study research group. For the prevention of cardiovascular disease, statins are a firstline treatment. Openurl1crossref2pubmed3web of science4 q in patients with type 2 diabetes mellitus, is atorvastatin better than. Rapid emergence of effect of atorvastatin on cardiovascular. The collaborative atorvastatin diabetes study cards 1 was a stunningly positive demonstration of the clinical benefit of statin therapy in patients with type 2 diabetes. An analysis from the collaborative atorvastatin diabetes study cards. Until recently, the role of statin therapy in diabetic patients without clinical signs or symptoms of coronary heart disease had been inadequately defined. Design a populationbased analysis with linked register data. The collaborative atorvastatin diabetes study cards is the first large primary prevention study to focus specifically on the role of a statin in patients aged 4075 years with type 2 diabetes, but no signs or symptoms of pre. The collaborative atorvastatin diabetes study cards is the first large primary prevention study to focus specifically on the role of a statin in patients aged 4075 years with type 2 diabetes, but no signs or symptoms of preexisting vascular disease and who had only average or below average cholesterol levels. In their analysis of the outcomes from cards, based on linear analysis, they determine the value of apolipoprotein b apob that corresponds to target values of ldl. In the collaborative atorvastatin diabetes study cards, the effect of lipitor atorvastatin calcium on cardiovascular disease cvd endpoints was assessed in 2838.
Methods the collaborative atorvastatin diabetes study cards is a multicentre, randomized, placebocontrolled, doubleblind clinical trial of primary prevention of cardiovascular disease in patients with type 2 diabetes. Cards abbreviation stands for collaborative atorvastatin diabetes study. An analysis from the collaborative atorvastatin diabetes study cards author links open overlay panel helen m. Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the collaborative atorvastatin diabetes study. Pdf baseline characteristics in the collaborative atorvastatin. Atorvastatin reduced cv events even in low ldl dm patients. We estimated the costeffectiveness of atorvastatin in the primary prevention of cardiovascular events in patients with type 2 diabetes using data from the collaborative atorvastatin diabetes study cards. To describe baseline characteristics of patients in the collaborative atorvastatin diabetes study cards, a randomized.
Design of the collaborative atorvastatin diabetes study cards. The role of statins in diabetes treatment diabetes spectrum. The objective of this study was to evaluate the safety and tolerability of atorvastatin 10 mg compared with placebo in 2,838 patients with type 2 diabetes and no history of coronary heart disease who were enrolled in the collaborative atorvastatin diabetes study cards. Intervention and event lowering in diabetes, cards collaborative atorvastatin diabetes study, aspen atorvastatin as prevention of coronary heart disease endpoints in patients with noninsulindependent diabetes mellitus, sparcl stroke prevention by aggressive reduction in cholesterol levels, and accord action to control. An overview of cards collaborative atorvastatin diabetes study primary prevention of cardiovascular disease with atorvastatin in type 2. Colhoun hm1, betteridge dj, durrington pn, hitman ga, neil ha, livingstone sj, thomason mj, mackness mi, charltonmenys v, fuller jh. Rapid emergence of effect of atorvastatin on cardiovascular outcomes in the collaborative atorvastatin diabetes study cards diabetologia, dec 2005 h. The collaborative atorvastatin diabetes study cards is a multicentre, randomized, placebocontrolled, doubleblind clinical trial of primary prevention of cardiovascular disease in patients with. The collaborative atorvastatin diabetes study cards. The goal of the collaborative atorvastatin diabetes study cards trial was to determine the effectiveness of the lipidlowering agent atorvastatin in reducing cardiovascular events and death among diabetic patients with at least one heart disease risk factor, but without elevated cholesterol. Ezetimibe added to statin therapy after acute coronary. Costeffectiveness of primary prevention of cardiovascular. Effects of atorvastatin on kidney outcomes and cardiovascular disease in patients with diabetes.
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